| abstract |
The invention relates to substituted propanamide compounds shown in the general formula (I), or stereoisomers, pharmaceutically acceptable salts or pharmaceutically acceptable solvates thereof. The invention also relates to medical composites containing the compounds, or the stereoisomers, pharmaceutically acceptable salts or pharmaceutically acceptable solvates of the compounds, and preparation methods and applications of the compounds in preparation of glucokinase activator. In the general formula (I), R1 is aryl-substituted/unsubstituted C1-10 linear/branched saturated/unsaturated alkyl or C3-10 cycloalkyl; R2 is substituent-substituted C1-10 linear/branched saturated/unsaturated alkyl, wherein the substituent is carboxyl, aryloxy, benzyloxy, hydroxyl, C1-4 alkylamidocarbonyl, C3-6 cycloalkylamidocarbonyl, C5-7 heterocycliccarbonyl or C5-7 heteroarylcarbonyl. |