http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102146040-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7c0a5a3e19633705b74da621161347d5 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-216 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C69-736 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-297 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-06 |
| filingDate | 2010-02-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-04-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_54cda06fc22ef42a45c08181b566db48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_43df2a4cba4ed327c444c10652100566 |
| publicationDate | 2014-04-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102146040-B |
| titleOfInvention | 2-(4-Chlorophenoxy)-2-methylpropionic acid methoxyphenyl propionate compound and synthesis method thereof |
| abstract | The invention discloses a 2-(4-Chlorophenoxy)-2-methylpropionic acid methoxyphenyl propionate compound which can be used for reducing cholesterol and low-density lipoprotein in a hyperlipidaemia model. By structural confirmation, the compound has the following structure that a synthesis method of the compound comprises the following steps of: taking 2-(4-Chlorophenoxy)-2-methylpropionic acid (1mol to 0.1mol), tetrahydro furan (100ml to 20ml), 1,3-dicyclohexylcarbodiimide (1mol to 0.1mol) and vanillin pyridine solution (1mol to 0.1mol); performing a reaction for 6 hours at a temperature of 10 DEG C to 30 DEG C; pouring reaction solution into water to obtain a crude product; carrying out recrystallization on the crude product by ethanol to obtain white solid; then adding malonic acid (1mol to 0.1mol) and pyridine (1mol to 0.1mol); and performing a reaction for 10 hours at a temperature of 100 DEG C to 120 DEG C to obtain white solid serving as the compound product. The compound has the yield of 85 percent. |
| priorityDate | 2010-02-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 51.