http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102145173-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7ca3568dc30a6560d19fcfcf0cc389ef |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08B37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2011-03-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2013-10-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cb0b2fcdddb9e8ab7529edb42227d175 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7328e91baf681a22e1f32108953d04d7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e0f5d3f7106944c8fac6e0a4bdb38748 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2603e6f780bd0f071aa6d7457c362c00 |
| publicationDate | 2013-10-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102145173-B |
| titleOfInvention | Human serum albumin complex hydrophobically modified pullulan nanoparticles and preparation method thereof |
| abstract | The invention relates to human serum albumin complex hydrophobically modified pullulan nanoparticles and a preparation method thereof. Hydrophobic group cholesterol, pullulan polysaccharides, succinic anhydride and human serum albumin are taken as raw materials for synthesis; the specific synthesis process is as follows: enabling the cholesterol and the succinic anhydride in the mass ratio of (1-2.5): 2 to react to firstly synthesize succinic anhydride cholesterol, and enabling the succinic anhydride cholesterol to react with the pullulan polysaccharides to synthesize cholesterol hydrophobically modified pullulan polysaccharides in the presence of a catalyst, wherein the mass ratio of cholesterol succinate (CHS) to sugar moiety of the pullulan polysaccharides is (1-4): 20; and performing further self-assembly on the hydrophobically modified pullulan polysaccharides to form a solution of the nanoparticles, then incubating the nanoparticles and the human serum albumin in a shaker for 9 hours, and finally getting the human serum albumin complex hydrophobically modified pullulan nanoparticles. The nanoparticles after complexation of the human serum albumin and the hydrophobically modified pullulan polysaccharide nanoparticles are shaped like spheres, and can maintain slow release effect of the medicament-loaded nanoparticles in a long lasting manner and stabilize plasma concentration. |
| priorityDate | 2011-03-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 62.