http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102144999-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5a843c3bc6ef616d46ada26b7194ec53 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-365 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10 |
| filingDate | 2010-02-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2013-05-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cc4fd4b959b9621b2532c92f9bb6b01c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b904206ae739917feb826ac519bb2ee3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dedeb04d6fdeae2ad9f30c07dacb1472 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2eb50919ae1dc5966d5a4facb63367a5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_03371dc3094262dd20e6e8c9b98aa935 |
| publicationDate | 2013-05-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102144999-B |
| titleOfInvention | Application of senkyunolide H in preparing medicine for preventing and curing cerebral apoplexy |
| abstract | The invention discloses a novel pharmaceutical application of senkyunolide H (represented by formula I). The invention adopts an animal model to study the influence of the senkyunolide H on the cerebral blood flow change in an MCAO (middle cerebral artery occlusion)-caused local cerebral ischemia reperfusion rat model and a KCl (potassium chloride)-induced cortical spreading depression rat model. Pharmacological results prove that senkyunolide H can remarkably increase the cerebral blood flow of a rat after MCAO modeling, and rapidly restore or even exceed the original cerebral blood flow before modeling after filling is performed, and show a certain brain protection effect. In addition, senkyunolide H can resist the cerebral blood flow decrease caused by KCl-induced rat local cerebral vasoconstriction, Therefore, senkyunolide H can be used for preparing a medicine for preventing and curing cerebral apoplexy. |
| priorityDate | 2010-02-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 32.