| abstract |
The present invention relates to cycloalkyl- or cycloalkenyl-substituted pyrazolopyrimidinones of formula (I): wherein A is selected from the group A 1 , and the group A 1 consists of C 3 -C 8 cycloalkyl or C 4 - C 8 cycloalkenyl composition, wherein the C 3 -C 8 cycloalkyl is selected from cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl and cyclooctyl; and the C 4 -C 8 ring Alkenyl is selected from cyclobutenyl, cyclopentenyl, cyclohexenyl, cycloheptenyl, cyclooctenyl, cyclopentadienyl, cyclohexadienyl, cycloheptadienyl, cyclooctadienyl Alkenyl, Cycloheptatrienyl, Cyclooctatrienyl, Cyclooctatraenyl. The compounds are useful for the preparation of medicaments, in particular for improving perception, concentration, learning and/or memory in patients in need thereof. Chemically, the compound is characterized as a pyrazolopyrimidone, and has a cycloalkyl moiety directly bonded to the 1-position of the pyrazolopyrimidone, and a optionally substituted methylene group at its 6-position The second substituent of the bridge. Other aspects of the invention relate to processes for the preparation of said compounds and their use for the manufacture of medicaments. |