abstract |
The present invention provides novel pyrimidine derivatives, pharmaceutical compositions thereof, and methods of using such compounds. For example, the pyrimidine derivatives of the present invention can be used to treat, improve or prevent the effects of inhibiting anaplastic lymphoma kinase (ALK) activity, c-ros oncogene (ROS), insulin-like growth factor (IGF-1R) and/or insulin receptors. InsRs (InsRs) or combinations thereof are responsive. |