http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102120036-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0cb011d981829bdcc85a40133a181da8 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K33-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-282 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2011-02-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2013-07-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_32461aef0a88faae3608e83ef141b612 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fb4df5f0332014563cd7565232f91e8e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0b9321a0183769872b1d633369cd173f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a2df5459813e997905fec92a7735f918 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_377e15b9af29ceb3cb3dc072ff02309b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eca7feeb31ccce9795ab1616bbdade89 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_67a5f2e29ebd3f4bc9e5625f37af3e25 |
| publicationDate | 2013-07-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102120036-B |
| titleOfInvention | Nano micelle of biodegradable macromolecular-bonding Pt(IV) anti-cancer medicament and preparation method thereof |
| abstract | The invention relates to a nano micelle of a biodegradable macromolecular-bonding Pt(IV) anti-cancer medicament and a preparation method thereof. The structural formula of the anti-cancer medicament is defined in the specification, wherein the biodegradable macromolecule is tri-block copolymer, namely polyethylene glycol-b-polyester-b-polylysine; and tetravalency platinum coordination compound Pt(IV) is connected with a side amino on the block of polylysine on a macromolecular carrier through alpha, omega-polyethylene glycol. The carrier is non-toxic and is water-soluble, thus being convenient for reacting with the platinum(IV) coordination compound in water phase; a nano micelle form can be formed through self assembly; a platinum(IV) coordination compound is reduced to platinum(II), namely, cis-platinum, Carboplatin or Oxaliplatin, and the anti-cancer effect is known; the synthesis of the nano micelle is easy; the reduction potential of platinum(IV) is low, so that the platinum(IV) can be rapidly reduced to platinum(II) in cancer cells to take treatment effect; and the platinum(IV) is connected to the side chain of the macromolecule rather than the end of a chain, a macromolecular chain can be connected with multiple platinum(IV)s, and the content of platinum can be as high as 10-20%. |
| priorityDate | 2011-02-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 116.