| abstract |
The invention discloses a preparation method of 5-aminobenzofuran-2-formate. The preparation method comprises the following steps: (1), using a compound III and a compound V to react in organic solvent under the action of alkali and prepare a compound II; and (2) using the compound II obtained in the step (1) and hydrogen to perform reduction reaction in organic solvent under the action of hydrogenation catalyst, wherein X is halogen and R is C1-C6 alkyl. The invention also discloses a preparation method of an intermediate of 5-aminobenzofuran-2-formate. The preparation methods of the invention have cheap and common raw materials, mild reaction conditions, simple operations and high synthetic efficiency, is helpful for industrial production and provides a new way for the preparation of vilazodone. |