| abstract |
The invention belongs to the field of drugs for treating angiogenesis-related diseases and provides pyrimidine derivatives with the structure in the general formula M or pharmaceutically acceptable salts thereof, wherein in the formula, R1 is hydrogen or methyl; and R2 is one of the following names of the compounds in the general formula M: M1: N4-(2-methyl-2H-indazole-6-yl)-N2-(cyclohexylamino)-pyrimidine-2,4-diamine; M2: N4-(2,3-dimethyl-2H-indazole-6-yl)-N2-(cyclohexylamino)-N4-methyl-pyrimidine-2,4-diamine; M3: N4-(2,3-dimethyl-2H-indazole-6-yl)-N2-(3-methyl-puperidyl)-N4-methyl-pyrimidine-2,4-diamine; and M4: N4-(2-methyl-2H-indazole-6-yl)-N2-(cyclohexylamino)-pyrimidine-2,4-diamine citrate. The invention also provides applications of the compounds or pharmaceutically acceptable salts thereof as drugs, especially anti-tumor drugs. |