| abstract |
The invention discloses a preparation method of o-hydroxyacetophenone and p-hydroxyacetophenone, which comprises the following steps: reacting phenol and acetic anhydride to obtain acetic acid phenol ester, and then adding acetate phenol ester to Lewis acid to obtain the product Use glacial hydrochloric acid for hydrolysis, stand still to separate the organic layer, freeze and filter the organic layer, recrystallize the obtained filter cake with water, and decolorize with activated carbon to obtain p-hydroxyacetophenone, freeze and filter the organic layer to obtain the filtrate After steam distillation and vacuum distillation, o-hydroxyacetophenone can be obtained. The invention adopts low raw material prices, mild experimental conditions, high experimental yield, and the ratio of ortho/para products can reach 1.4:1, which has good popularization and application value. |