http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102089328-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y304-24029 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-3153 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-78 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-09 |
| filingDate | 2009-03-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-10-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-10-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102089328-B |
| titleOfInvention | Streptokinase mutant and covalent modification thereof |
| abstract | The present invention relates to the new mutant of streptokinase, its function fragment and covalent modification.Preparation antibacterial plasminogen activator protein streptokinase, its mutain, specie variants and the method for their covalent modification variant are provided, their feature is the therapeutic properties improved, the fibrin clot specificity of proteolytic stability, the plasma half-time of prolongation, the immunoreactivity of reduction and enhancing as increased.Described method relates to mixing extra cysteine residues in the nonessential region of protein or replacing naturally occurring aminoacid with cysteine residues so that the catalysis activity of gained protein keeps major part constant.These cysteine variants sulfydryl reactivity structure division by covalently bound cysteine reactive polymer such as Polyethylene Glycol (PEG) or from the group including fluorogen, spin label or other little conjugates is modified further.The locus specificity biologically active conjugates of streptokinase and its covalent modification variant is disclosed herein. |
| priorityDate | 2008-03-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 177.