http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102086198-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b4711b7defc1422cdb7f86d2c95657bf |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 |
| filingDate | 2009-12-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2013-05-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_64a039d9c2482cc2674ad8347fb15e96 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dcb0ef84596db95caec7de7dd45806cf |
| publicationDate | 2013-05-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102086198-B |
| titleOfInvention | Method for preparing 1,2-dihydroisoquinoline compounds of pyrazole ring |
| abstract | The invention belongs to the field of organic chemistry, and relates to a method for preparing 1,2-dihydroisoquinoline compounds of a pyrazole ring. The structure of the compounds is represented and confirmed by a method such as 1H NMR (nuclear magnetic resonance), 13C NMR, HRMS (high resolution mass spectrometry), and single-crystal X diffraction. The method comprises the following steps of: performing intramolecularcyclization on acetonitrile and N,N-dimethylformamide of which the v/v is 1:3, and adjacent alkynyl substituted benzaldehyde hydrozones at room temperature by using silver trifluoromethanesulfonate as a catalyst, performing nucleophilic addition reaction with silyl enol ether, performing intramolecular condensation and aromatization, and efficiently preparing the 1,2-dihydroisoquinoline compounds of the pyrazole ring by using a one-pot method. In the method, reaction conditions are mild, a substrate has a wide applicable range, a few side reactions are generated, and the product has high purity and is easy to separate and purify; and the method is easy and convenient to operate and low in cost, can be applied to large-scale preparation and has good application prospect. |
| priorityDate | 2009-12-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 40.