| abstract |
The present invention provides a preparation method of 1-biphenylmethylimidazole compound with superior angiotensin II receptor antagonistic activity, or its intermediate. The present invention provides a method for preparing a compound of formula (5) (R 1 , R a : H, alkyl) by using an oxidant to oxidize a compound of formula (1) (R a : H, alkyl) in the presence of a free radical initiator, And subsequently react with an ammonia generator and a compound of formula R 1 CHO (R 1 H, alkyl) or a compound of formula R 1 C(OR b ) 3 (R 1 : H, alkyl; R b : alkyl). |