| abstract |
The present invention provides compounds according to formula (I) or (II), and pharmaceutical compositions comprising these compounds, wherein R 1 , R 4 and R 5 are as defined in the present invention. Such compounds and compositions are useful for modulating indoleamine-2,3-dioxygenase activity; treating immunosuppression mediated by indoleamine-2,3-dioxygenase (IDO); treatment may benefit Inhibition of the enzymatic activity of indoleamine-2,3-dioxygenase in medical conditions; enhancing the effectiveness of anticancer therapy with anticancer drugs; treatment of tumor-specific immunosuppression associated with cancer; and treatment of infectious Disease-related immunosuppression. |