| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_05080baeccdb4c6cf192e0cd8ab86cdb |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-519
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-53
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D519-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-519
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01N43-54
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate |
2008-10-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2014-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a6ac120456e82e6d89a4775774988fd6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_99885e76309885043bd180bec5f2bf8c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f0160081a904c7b07d04364b9d93d9f8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_da85786043f3edcfdd040ed77796387e |
| publicationDate |
2014-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-102083314-B |
| titleOfInvention |
PARP inhibitor compounds, compositions and methods of use |
| abstract |
The present invention relates to tetraaza phenalen-3-one compounds which inhibit poly (ADP-L-ribose) polymerase (PARP) and are useful in the chemosensitization of cancer therapeutics. The induction of peripheral neuropathy is a common side-effect of many of the conventional and newer chemotherapies. The present invention further provides means to reliably prevent or cure chemotherapy- induced neuropathy. The invention also relates to the use of the disclosed PARP inhibitor compounds in enhancing the efficacy of chemotherapeutic agents such as temozolomide. The invention also relates to the use of the disclosed PARP inhibitor compounds to radiosensitize tumor cells to ionizing radiation. The invention also relates to the use of the disclosed PARP inhibitor compounds for treatment of cancers with DNA repair defects. |
| priorityDate |
2007-10-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |