http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102058535-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9ab0eb9804b011d4b5833a5c571bb8e5 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-127 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2010-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2013-05-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_42016f25c4a0ab8e58e19316d14a326f |
| publicationDate | 2013-05-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102058535-B |
| titleOfInvention | Novel folate receptor targeted liposome |
| abstract | The invention discloses a novel folate receptor targeted liposome, which can exclusively inhibit growth of cells of neuroblastoma and consists of distearoylphosphatidylcholine, cholesterol, 1,2-dioleic-3-dimethyl amide propane, polyethylene glycol-CerC16, folate and siRNA of MYCN gene. The liposome has high delivery efficiency in cells of neuroblastoma where a folate receptor is highly expressed and the finally proportion of liquid/oligonucleotides achieves 0.15-0.25 (w/w). The novel liposome maintains the objective siRNA after general administration for a considerably long period of time in blood circulation. The study represents that the targeted liposome carried with siRNA gene, which is served as the product of the invention, is delivered to LA-N-5 cells by the folate receptor, which obviously inhibits MYCN gene expression and cell growth. The liposome has strong capacity of inhibiting cells of neuroblastoma where the folate receptor is over-expressed and can be used as a medicine for potential targeted treatment of neuroblastoma. |
| priorityDate | 2010-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 219.