http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102050800-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_72dacf4ff825940489434f2fbec05053 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-096 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-096 |
| filingDate | 2009-11-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2013-05-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_44032be594499b86f609cd37a5100e0f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_08b48312253725222f045c5ac6f539e2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7064a03701643e18ce7220540eb823b4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3d06e1b16234e77b947f9de78504a65e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7a623ba64a7e43cc5e7244f9bbb3671c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_94813ae1a53f57fcd0406fd514ad1402 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e9996f43fc74bebb5fcdfab35cd23e63 |
| publicationDate | 2013-05-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102050800-B |
| titleOfInvention | Method for preparing optical isomers of 1-butyl-2-hydroxyarylalkanol piperazine derivative |
| abstract | The invention relates to a method for preparing (1S and 2S) and (1R and 2R) optical isomers of 1-butyl-2-hydroxyarylalkanol piperazine derivative, particularly N1-benzyl-N4-[1-butyl-2-(5'-chloro-6'-methoxy-2'-naphthyl) hydroxyethyl] piperazine (shown as a formula A) and diastereoisomer salts formed by the optical isomers and a splitting reagent. The method comprises the following steps of: dissolving mixture of (1S and 2S) and (1R and 2R) formula A compound optical isomers, particularly raceme and chiral mandelic acid or derivatives thereof in a proper solvent to perform reaction, settling the generated (1S and 2S)-forma A compound-R-(-)-mandelic acid or derivative salt thereof or (1R and 2R)-forma A compound-S-(+)-mandelic acid or derivative salt thereof respectively, and then performing alkalization to obtain corresponding (1S and 2S) or (1R and 2R) forma A compound optical isomers. |
| priorityDate | 2009-11-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 78.