http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102040650-B

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assignee http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3ef51fdb073e948cd3b75aaad623784a
classificationIPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J75-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J53-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J21-00
filingDate 2010-10-26-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2014-03-26-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_625558f055035520910956983b2e9326
publicationDate 2014-03-26-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-102040650-B
titleOfInvention Method for constructing sterides-6beta, 7beta-methylene structure by cascade reaction
abstract The invention discloses a method for constructing a sterides-6beta, 7beta-methylene structure by a cascade reaction, which comprises the following step that: a 3beta-R3O-5alpha-hydroxy-6beta, 7beta-sterides compound is prepared by the cyclomethylenation reaction of a 3beta-R3O-7alpha-R7-5appha, 6alpha-epoxy-sterides compound serving as a raw material and a methylenation reagent under the complexing action of an inorganic metal salt or an organic metal compound and the initiation action of an initiator. The method has the advantages of readily available materials, fewer reaction steps, simplicity of operation, high stereoselectivity for constructing the 6beta, 7beta-methylene structure unit and high yield of target compounds, and suitability for industrial production.
priorityDate 2010-10-26-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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