http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102040646-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_72f80da51b3db772f503ff12ae7597e6 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J75-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J71-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J5-00 |
| filingDate | 2009-10-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8b4cdaca16e9bd5379dd6fa34d0ce669 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ab9c858d0bb1bfc614cd17c394ea76d2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ef6703f66704dce1db5a6452a2b56ca1 |
| publicationDate | 2011-05-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102040646-A |
| titleOfInvention | Synthetic process for preparing 6alpha-fluoro steroids by using NFTh fluorinating agent |
| abstract | The invention discloses a synthetic process for preparing 6alpha-fluoro steroids by using an NFTh fluorinating agent. Compounds in a formula (II) are reacted with a fluorine reagent in a formula (III) in an organic solvent to form compounds in a formula (I), wherein R1 is H, halogen or OH; R2 is H, alpha-OH or alpha-C1-5 acyloxy; R3 is H, OH, or alpha and beta C1-3 alkyl; R2 and R3 are alpha epoxy or double bond; 15 and 16 are carbon at positions 15 and 16 of steroidrings; M and Q are respectively H or alkyl with 1 to 6 carbon atoms, such as methyl and cyclohexyl, and also can be five-membered or six-membered heterocycle containing an O or N heteroatom, such as furan, pyridine, piperidine and the like; R4 is H or alpha and beta hydroxyl; R5 is H or alpha halogen; R4 and R5 are beta epoxy or double bond; R6 is H or alkyl with 1 to 4 carbon atoms; the serpentine in the molecular formulas refers to a substituent group alpha or beta; and real and virtual lines between positions 1 and 2 refer to single bond or double bond. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113896759-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107778342-A |
| priorityDate | 2009-10-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
| Predicate | Subject |
|---|---|
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID467711449 |
Total number of triples: 18.