http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102040645-A
Outgoing Links
Predicate | Object |
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assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_72f80da51b3db772f503ff12ae7597e6 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J71-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J75-00 |
filingDate | 2009-10-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8b4cdaca16e9bd5379dd6fa34d0ce669 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ab9c858d0bb1bfc614cd17c394ea76d2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ef6703f66704dce1db5a6452a2b56ca1 |
publicationDate | 2011-05-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | CN-102040645-A |
titleOfInvention | Synthetic process for preparing 6alpha-fluoro steroids by using NFOBS or NBSI fluorinating agent |
abstract | The invention discloses a synthetic process for preparing 6alpha-fluoro steroids by using an N-fluoro-O-benzenedisulfonimide (NFOBS) or N-fluorobisbenzenesulphonimide (NBSI) fluorinating agent. Compounds in a formula (II) are reacted with the fluorinating agent in an organic solvent to form compounds in a formula (I), wherein R1 is H, halogen or OH; R2 is H, alpha-OH or alpha-C1-5 acyloxy; R3 is H, OH, or alpha and beta C1-3 alkyl; R2 and R3 are alpha epoxy or double bond; 15 and 16 are carbon at positions 15 and 16 of steroidrings; M and Q are respectively H or alkyl with 1 to 6 carbon atoms, such as methyl and cyclohexyl, and also can be five-membered or six-membered heterocycle containing an O or N heteroatom, such as furan, pyridine, piperidine and the like; R4 is H or alpha and beta hydroxyl; R5 is H or alpha halogen; R4 and R5 are beta epoxy or double bond; R6 is H or alkyl with 1 to 4 carbon atoms; the serpentine in the molecular formulas refers to a substituent group alpha or beta; and real and virtual lines between positions 1 and 2 refer to single bond or double bond. |
isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113896759-A |
priorityDate | 2009-10-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 23.