| abstract |
The present invention relates to a compound of formula I, wherein R 1 is (II) or (III), R 2 , R 4 and R 6-9 are as defined herein, and to pharmaceutically acceptable salts and esters of the compound. These compounds inhibit PI3 kinase and mTOR and are useful in the treatment of various diseases mediated through PI3 kinase and mTOR, such as various cancers. The present invention discloses methods for making the compounds of the invention and using the compounds of the invention. Various compositions containing the compounds of the invention are also disclosed. |