| abstract |
The present invention relates to the promoter region of microRNA, the use of microRNA, especially miR-21, and related components used for diagnosis and related to the preparation of medicines for treating and/or preventing fibrosis and/or fibrosis-related diseases Element. In addition, the present invention relates to antisense oligonucleotides directed against targets of miR-21. Also included are miR-21-deficient cells, promoter regions, and targets of miR-21 and their knockout organisms. Finally, the present invention relates to methods for diagnosing fibrosis and/or fibrosis-related diseases as well as methods for screening pharmaceutically active compounds for the treatment of fibrosis and/or fibrosis-related diseases. The present invention also relates to compositions for treating, improving and/or preventing fibrosis. In certain embodiments, the compositions modulate the activity of miRNAs for the treatment, amelioration and/or prevention of fibrosis. In certain embodiments, the compositions inhibit the activity of miR-21 for the treatment, amelioration and/or prevention of fibrosis. |