| abstract |
The present invention provides a compound of formula (I) or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, wherein the variables A, L 1 , L 2 , R 2 , R 11 and M are as defined herein. These compounds are selective inhibitors of coagulation factor XIa or dual inhibitors of fXIa and plasma kallikrein. The invention also relates to pharmaceutical compositions comprising such compounds, and methods of using such compounds to treat thromboembolic and/or inflammatory disorders. |