http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102020647-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ebd866d29998881cc37223edf83ca315 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_072ca7528ec7345afd81ae0e17fb5e05 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5eb68550957fae9fa2d2b4a609df00bc |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C323-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C319-20 |
| filingDate | 2010-11-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2013-09-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_985b28c67a5b9ce1f1e215b73026f9bf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7bfd07d8996e1962fd1af0209148be52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_045994359a8e3b530bb54dde1b2e8c52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f46f4f82830bfb71d8c934ba45c749ab http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_21d5b47ed369b5a30fce70b83ecfd292 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d1dc5743efa7b2d8ef3c6f29c920cdc4 |
| publicationDate | 2013-09-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102020647-B |
| titleOfInvention | 1-(2,2-difluoroethoxy)-6-trifluoromethyl-N-([1,2,4]triazol[1,5-c]pyrimidine-2-)benzenesulfonamide Preparation |
| abstract | The invention provides a 1-(2,2-difluoroethoxy)-6-trifluoromethyl-N-([1,2,4]triazol[1,5-C]pyrimidine-2 -) The preparation method of benzenesulfonamide comprises the steps of: taking the compound shown in formula (IV) as starting material, synthesizing the compound shown in formula (III), then synthesizing the compound shown in formula (II), and finally synthesizing The target product of formula (I), the present invention makes two phenolic alcohols docked to form ether, avoiding the need to introduce difluoroethoxy groups with expensive and unmarketable 2,2-difluorobromoethane as a reagent, in the synthesis of the target product In the process, in addition to using 3,5-lutidine and dimethyl sulfoxide, a catalytic amount of 18-crown 6 crown ether was used, so that the reaction time and yield were improved. The invention simplifies the reaction conditions, optimizes the synthesis process, improves the reaction yield and reduces the production cost, thereby greatly improving the synthesis effect. The general reaction formula is as follows: |
| priorityDate | 2010-11-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 40.