abstract |
The present invention relates to the NIP thiazole of the formula (I) as 11-beta-hydroxy steroid dehydrogenase type 1 (11-β-HSD-1) enzyme selectivity inhibitor, and these compounds are used for the treatment of the purposes with prevention of metabolic syndrome, diabetes, insulin resistant, obesity, lipid disorders, glaucoma, osteoporosis, cognitive disorder, anxiety, depression, immunological diseases, hypertension and Other diseases and disease. |