| abstract |
A compound represented by the following formula (I) or a salt thereof has excellent CRF receptor antagonistic activity, and has sufficient pharmacological activity, safety, and in vivo dynamics as a drug. [In the formula, R 1 represents the formula-A 11 -A 12 ; R 2 represents tetrahydrofuryl methyl, tetrahydropyranyl methyl or tetrahydropyranyl; A 11 represents a single bond, methylene or 1,2 -Ethylene; A 12 represents C1-6 alkyl, C3-6 cycloalkyl or C3-6 cycloalkyl with methyl; R 3 represents methoxy, cyano, cyclobutyloxymethyl, Methoxymethyl or ethoxymethyl; R 4 represents a methoxy group or a chlorine atom. ] |