| abstract |
The present invention provides targeting lipids having the structure (CI) L 100 -Linker-L 101 , wherein L 100 is a lipid, lipophile, alkyl, alkenyl or alkynyl and L 101 is a ligand or -CH 2 CH 2 (OCH 2 CH 2 ) p O(CH 2 ) q CH 2 -ligand, p is 1-1000 and q is 1-20. Additionally, the present invention provides compositions and methods for delivering therapeutic agents to cells. In particular, these include novel lipid and nucleic acid-lipid microparticles that provide efficient encapsulation of nucleic acids and efficient delivery of encapsulated nucleic acids to cells in vivo. |