http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102002001-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d8e56bfdfbc0bb3219360ec9a05b25a4 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D235-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4184 |
| filingDate | 2010-11-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2013-02-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_421360bb5b9409b3c4b7ac25a93798a0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_233a8be817fbebb57b99350f9fc8734e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1fc87d4726b29b664644a6b43ff08402 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_00eed098e7965bafb5786b0d0fd3f886 |
| publicationDate | 2013-02-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102002001-B |
| titleOfInvention | 2,2'-(1,4-phenylene) di(benzimidazole-5-carboxylic acid) and preparation method thereof |
| abstract | The invention discloses a 2,2'-(1,4-phenylene) di(benzimidazole-5-carboxylic acid), which has a chemical structural formula as shown in the specification. A preparation method of the 2,2'-(1,4-phenylene) di(benzimidazole-5-carboxylic acid) comprises the following steps: dissolving 3,4-diaminobenzoic acid into non-proton polar solvent; heating the mixture to certain temperature through oil bath; dropwise adding the non-proton polar solvent solution of terephthalaldehyde, and stirring for a certain time after finishing the dropping; adding oxidant into a reaction system, and continually stirring the mixture and reacting for a certain time; and adding the reaction liquid into ethanol; and filtering, drying to obtain light brown solid, namely the 2,2'-(1,4-phenylene) di(benzimidazole-5-carboxylic acid). The non-proton polar solvent is selected from one or more of tetrahydrofuran, acetonitrile, N-pyrrolidone extraction N, N,N-dimethylformamide, and dimethylsulfoxide; the oxidant is selected from one or more of cerium ammonirm nitrate, oxyful, ferric trichloride, cupric acetate, oxalic acid iodobenzene, air, oxygen, benzoquinone, dichloro dicyan benzoquinone, 3-nitro-4-aminobenzoic acid and 3-amino-4-nitrobenzoic acid. The invention also relates to application of the 2,2'-(1,4-phenylene) di(benzimidazole-5-carboxylic acid) in the preparation of antineoplastic agents. |
| priorityDate | 2009-12-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 27.