http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-101993406-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_066af93d226b9a8b1151cb1bc45bd190 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_10c3f12979e7751f6e54ae5594988766 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-08 |
| filingDate | 2009-08-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-01-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0ec5b0560c6ee04b6462e6be9db696a8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b2fab8ed7960345097c04211c3821589 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f5d6218a9755b4e7d4185aaeba0dddce http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d52bd7636f170745092423ee13952d4b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_392a06760b8a593e8b3b4f1015cc7e45 |
| publicationDate | 2014-01-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-101993406-B |
| titleOfInvention | Indoline compound with optical activity and preparation method thereof |
| abstract | The invention provides an indoline compound with optical activity, namely R-5-(2-amidopropyl)-1-(3-(4-fluorine benzoyl oxygen group) propyl)-7-cyan indoline. The compound can be used as a key intermediate and used for preparing a chiral drug, namely, Silodosin. The invention also provides a preparation method of R-5-(2-amidopropyl)-1-(3-(4-fluorine benzoyl oxygen group) propyl)-7-cyan indoline, which is characterized by comprising the following steps: taking 1-(3-(4-fluorine benzoyl oxygen group) propyl)-5-(2-nitrylpropyl)-7-cyan indoline as a raw material to obtain the 1-(3-(4-fluorine benzoyl oxygen group) propyl)-5-(2-oxopropyl)-7-cyan indoline, carrying out asymmetric reaction on the 1-(3-(4-fluorine benzoyl oxygen group) propyl)-5-(2-oxopropyl)-7-cyan indoline and a cheap chiral auxiliary agent, namely alpha-phenylethylamine, wherein asymmetric inductivity is 6:1, and finally removing protective group. |
| priorityDate | 2009-08-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 62.