| abstract |
A formula (I) cyclopentadien[g] quinazoline derivative containing L-Glu-γ-D-Glu dipeptide group: wherein: R 1 is amino, C 1-4 alkyl, C 1-4 hydroxyalkyl, C 1-4 fluoroalkyl or methoxy-C 1-4 -alkyl; R 2 is hydrogen, C 1-4 alkyl, C 3-4 alkenyl, C 3 -4 alkynyl, C 2-4 hydroxyalkyl, C 2-4 haloalkyl or C 1-4 cyanoalkyl; and Ar is phenylene, thiophene optionally with one or two substituents Diyl, thiazolediyl, pyridinediyl or pyrimidinediyl, the substituents are selected from halogenated, hydroxyl, amino, nitro, cyano, trifluoromethyl, C 1-4 alkyl and C 1-4 alkoxy. Compound (I) is optionally in the form of a pharmaceutically acceptable salt or ester; useful for the treatment of rheumatoid arthritis or acute myelogenous leukemia. |