| abstract |
The invention discloses a class of ester derivatives with the structure of formula I and pharmaceutically acceptable salts thereof. Wherein, R 1 is halogen; R 2 , R 3 , R 4 are simultaneously or separately: hydrogen, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, halogen, nitro, nitrile, phenyl ; R 5 is: hydrogen, C 1 -C 4 linear or branched chain alkyl, halogen, nitro, nitrile, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, amino, C 1 -Phenyl substituted by C 4 alkanoyl amido; R 6 is: C 1 -C 4 straight chain or branched chain alkyl. The invention also discloses the preparation method of the above-mentioned compound, and at the same time discloses the pharmaceutical composition using the compound or its pharmaceutically acceptable salt as the active ingredient, and their use as anti-platelet aggregation drugs, especially in the preparation of The application of drugs for the prevention or treatment of coronary syndrome, myocardial infarction, myocardial ischemia and other cardiovascular and cerebrovascular diseases caused by platelet aggregation. |