http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-101962371-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d40285e27f4ed83b8728b0d477404958 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8b317eaaf6beca519ef4351d0a0da360 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D285-08 |
| filingDate | 2010-10-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2013-07-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4aec5abf6e7aeb1bf99283299bf53ee0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d29bdfab9c9017c64f8b8834319397ad http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a24a8f5e17ab18df930360f4c21c170e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bdc7003c2384b74a26bbca5cfe1d223f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f1c0e9098a8e347b7be0e3086a2c786f |
| publicationDate | 2013-07-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-101962371-B |
| titleOfInvention | Method for preparing ceftobiprole side chain acid and key intermediate thereof |
| abstract | The invention discloses a method for preparing ceftobiprole side chain acid shown as a formula (I) and a key intermediate thereof, namely a 5-amino-1,2,4-thiadiazole-3-acetamide derivative (II), which comprises the following steps of: performing rearrangement reaction on 3-amino-5-amido isoxazole (III) and an isothiocyanate compound (IV) in an organic solvent to generate the 5-amino-1,2,4-thiadiazole-3-acetamide derivative (II); performing oximation and hydroxy protection of oxime to obtain a (Z)-2-(5-amino-1,2,4-thiadiazole-3-yl)-2-(triphenylmethoxy)imino acetamide derivative (V); and finally performing basic hydrolysis to obtain the ceftobiprole side chain acid (I). The method mainly has the advantages of simple and readily available raw materials, mild reaction conditions, simple and convenient posttreatment, simple operation and the like, so the method has high implementation value and social and economic benefits. |
| priorityDate | 2010-10-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 107.