http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-101959534-A

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publicationDate 2011-01-26-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-101959534-A
titleOfInvention Enzyme and Receptor Regulation
abstract Covalent conjugates of α,α-disubstituted glycine esters to target intracellular enzymes or modulators of receptor activity, wherein the ester group of the conjugate is hydrolyzable by one or more intracellular carboxylesterases into the corresponding acid, and the coupling position of the α, α-disubstituted glycine ester and the regulator is far away from the binding interface between the inhibitor and the target enzyme or receptor, and enters the cell, while the active acid hydrolyzate accumulate in cells.
priorityDate 2008-02-29-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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Total number of triples: 26.