abstract |
The present invention relates to insulin derivates, this insulin derivates is the naturally occurring Regular Insulin or its analogue that are connected to side chain at the alpha-amino group place of parent insu B chain-terminal amino acid residue or the epsilon-amino place of Lys residue that exists on parent insu B chain, this side chain have following general general formula :-W-X-Y-Z wherein W, X, Y and Z as in this specification sheets define. |