http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-101955481-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D473-18 |
| filingDate | 2010-10-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-04-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-04-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-101955481-B |
| titleOfInvention | A kind of preparation method of Valganciclovir hydrochloride |
| abstract | The invention discloses a kind of preparation method of Valganciclovir hydrochloride I, step is: 1. phosphorus oxychloride is dissolved in inert solvent, reacts with alcohol liquid, obtains phosphinylidyne dihalo-II; 2. ganciclovir and step phosphinylidyne dihalo-II are 1. obtained by reacting ganciclovir monoesters III; 3. step ganciclovir phosphate monoester III is 2. obtained ganciclovir dibasic acid esters IV with the esterification of N-benzyloxy-oxo-L-valine; 4. step ganciclovir dibasic acid esters IV acidifying dephosphorylation is 3. obtained N-benzyloxy-oxo-L-valine ganciclovir monoesters V; 5. last step product is 4. obtained Valganciclovir hydrochloride reason I by hydrogenation.The method produces the ganciclovir monoesters of high purity, high yield.Its aftertreatment is more prone to, and reduces post-processing difficulty. |
| priorityDate | 2010-10-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 80.