abstract |
Compounds that inhibit PI3Kd activity, including compounds that selectively inhibit PI3Kd activity, are disclosed. Methods of inhibiting phosphatidylinositol 3-kinase delta isoform (PI3Kd) activity, and methods of treating diseases, such as disorders of immunity and inflammation in which PI3Kd plays a role in leukocyte function, using the compounds also are disclosed. |