http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-101948418-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_653c418e41edbb4e1ce8bc5e53e70cec |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-635 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-16 |
| filingDate | 2010-08-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5c57790ee3621bcd7a35c4a3b463356b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8e929a4b977885d4e748265971c52298 |
| publicationDate | 2011-01-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-101948418-A |
| titleOfInvention | Hydroxyproline structure-containing HIV-1 protease inhibitor as well as preparation method and application thereof |
| abstract | The invention relates to a hydroxyproline structure-containing HIV-1 protease inhibitor as well as a preparation method and application thereof, belonging to the field of chemical drugs. A compound has the structure shown as the general formula 7 in the description. The preparation method comprises the following steps of: combining a Boc-protecting amine chiral alcohol compound as a raw material with a hydroxyproline methyl ester with hydroxyl being activated by a DSC (Dynamic Stability Control) reagent to generate carbamate, then hydrolyzing under alkali conditions to obtain corresponding carboxylic acid, carrying out condensation reaction with different amines to generate a series of amide derivatives, removing a Boc-protecting group and reducing nitro to synthesize a series of novel hydroxyproline structure-containing HIV-1 protease inhibitors. The target compound has strong HIV-1 protease inhibition activity and is used for preparing anti-AIDS drugs. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103073473-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102627654-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103073473-A |
| priorityDate | 2010-08-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
| Predicate | Subject |
|---|---|
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-101481346-A |
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID467435040 |
Total number of triples: 19.