| abstract |
The invention provides a kind ofly have the effect of strong GHS-R agonist, as the useful compound of general wasting diseases curative of emaciation etc.It is that (in the formula, X represents CH to general formula (1a)n 2 , C=O, CH-OR, CH-SR or CH-NRR '; M represents 1 or 2 number; Ar represents phenyl, naphthyl, contain the five-ring that is selected from 1 or 2 atom among S, N and the O or heteroaromatic formula group of six-ring etc.; Rn 1 And Rn 2 Identical or different, expression hydrogen atom or methyl; Rn 3 The alkyl of expression carbonatoms 1～6 etc.; N represents 0 or 1 number; Rn 4 And Rn 5 Identical or different, the alkyl of expression hydrogen atom, carbonatoms 1～6 etc., Rn 6 , Rn 7 , R and R ' be identical or different, the alkyl of expression hydrogen atom, carbonatoms 1～6) represented 3,8-diamino tetrahydroquinoline derivative or its salt. |