| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_70deb6ae26886829435c0284fa02d424
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_57fa60a0cac09d94577be5413e9c1e30 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-19 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-56
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-21
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-21
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-21
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-12 |
| filingDate |
2010-06-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2013-07-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0e11172adb07549248156d5eed7c9622
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d50d9d79304b3da4623d386d3eb52b1c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a650ee789dc2c3df138559d8b118cf1c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_af88069c4ba744bfe4af6c7a731627f3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_184c6084d807a01d0fc8531203939cf5 |
| publicationDate |
2013-07-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-101921330-B |
| titleOfInvention |
Recombinant human interferon alpha 1b mutant and preparation method thereof |
| abstract |
The invention belongs to the field of biomedicine and relates to an interferon alpha 1b mutant, a preparation method thereof and use thereof in preparing a medicament for treating and/or preventing viral infectious diseases. The technical means of the invention comprises the following steps: reconstructing the existing interferon alpha 1b molecule by performing sequence analysis and combining the structural characteristics of interferon alpha 1b, interferon alpha 2a and interferon alpha 2b; replacing the 26th site by an Leu, replacing the 27th site by a Phe and/or replacing the 31st site by an Lys and enabling high expression thereof; establishing a method for purifying a new molecule; and measuring the bioactivity of the new molecule by a WISH/VSV method to finally obtain a high-activity interferon alpha 1b mutant. |
| priorityDate |
2010-06-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |