| abstract |
The invention relates to a naphthaline amide derivative and a preparation method and application thereof. The structure of the naphthaline amide derivative is shown in the general formula (I), wherein the definitions of R1, R2, R3, R4 and Z are shown in the specification. The naphthaline amide derivative has protein kinase inhibiting activity and histone deacetylase inhibiting activity, can be used for treating diseases related to protein kinase activity abnormality or histone deacetylase activity abnormality, wherein the diseases comprise phlegmonosis, autoimmune diseases, cancers, nerve system diseases, neurodegeneration diseases, angiocardiopathy, metabolic diseases, hypersusceptibility, asthma and diseases related to hormone. |