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filingDate 2010-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2013-06-12-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1248e08a18cb3cfc6131187b075b8ec3
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publicationDate 2013-06-12-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-101885681-B
titleOfInvention Supercritical carbon dioxide extraction technology for pleuromutilin
abstract The invention relates to extraction technologies for microorganism-sourced compounds, in particular to a supercritical carbon dioxide extraction technology for pleuromutilin. The technology comprises the following steps: separating mycelium from pleuromutilin producing strain fully-fermented liquor, drying, smashing, screening, baking to obtain baked mycelium with total water content less than 5%for stand-by application, putting the baked mycelium in a supercritical extraction kettle to carry out supercritical carbon dioxide extraction under extraction pressure of 12-24Mpa and at extraction temperature of 35-55 DEG C and carbon dioxide flow rate of 25kg/h for 60-100min, and collecting extract to obtain the pleuromutilin. The technology has the advantages of stable and easy operation, short extraction time and low production cost and requires small amount of solvents; and moreover, the products has little impurities.
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