| abstract |
The invention relates to a beta-hydroxyisovalerylshikonin derivative and a preparation method thereof. Factors R1and R2 in a structural formula I of the beta-hydroxyisovalerylshikonin derivative are H, alkyl of 1-6 carbon atoms and phenyl, R3 is H, methyl, ethyl and ethanol; R1 in a structural formula II is oxygen heterocyclic ring; and R1 in a structural formula III is H, methyl and ethanol and R2 is H and alkyl of 1-4 carbon atoms. Because the selectivity inhibition of beta-hydroxyisovalerylshikonin on tumor cells has great relation with hydroxy of a side chain ester bond B position, analogues (ester or ether containing oxygen in a side chain hydroxyl beta position) of a series of beta-hydroxyisovalerylshikonin are designed by using the beta-hydroxyisovalerylshikonin as precursors for anti-tumor activity selection to obtain an anti-tumor compound with target function and brand new structure. The structural formulas I, II and III are shown in the specification. |