http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-101857618-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H17-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H15-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7064 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2010-06-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-11-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2015-11-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-101857618-B |
| titleOfInvention | As series of quinazoline sugar derivatives thing, its preparation method and the application of protein tyrosine kinase inhibitor |
| abstract | The invention provides a kind of quinazoline sugar derivative and its preparation method and application, the problem that the suppression tyrosine kinase activity of prior art existence is not high can be solved, and the quinazoline sugar derivative that the present invention obtains is water-soluble, to human skin cancer cells A431 inhibit activities all better, can be applicable to the medicine preparing prevention or treatment tumour.Quinazoline sugar derivative provided by the invention is that a class formation is novel, quinazoline female ring 6-position side chain contains the compound enriching glycosyl fragment, the raw material of the glycosylation process of quinazoline ring is easy to get, synthetic method is simple, way of purification is simple and efficient, and quinazoline sugar derivative of the present invention is better water-soluble, there is better biological activity especially have EGFR and select inhibit activities significantly, there is significant antitumor efficacy, therefore this compounds prevention or treatment tumour medicine in have a wide range of applications.The structural formula of quinazoline sugar derivative is as figure. |
| priorityDate | 2010-06-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 104.