http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-101857589-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_db9efde660b78f98b102046e09d07ab7 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5377 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-02 |
| filingDate | 2010-06-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2013-12-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_90f6cc0d9af59df8e3bcf4522fadfa8d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f068509e3238915e111bc4c05be100e5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1d232d21eed68034c814c146053808a5 |
| publicationDate | 2013-12-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-101857589-B |
| titleOfInvention | Pyrazol-benzimidazoles derivative and application thereof |
| abstract | The invention discloses a pyrazol-benzimidazoles derivative and application thereof. The pyrazol-benzimidazoles derivative has a structure shown as a formula (I). Pharmacological tests show that the derivative as a compound or pharmaceutically acceptable salts thereof have an inhibitory action on the proliferation of multiple tumour cells, wherein an A ring is substituted or non-substituted pyrimidine or pyrazine; a substituting group is halogen, nitryl, cyano-group, sulfydryl or amino; R1 is alkyl, haloalkyl, alkoxy, alkylthio group, alkyl sulfonyl, thiophenyl, thiophenyl substituted by naphthenic base amide, phenoxy substituted by the naphthenic amide and acyl or ester group; R2 is hydrogen, the halogen or -NR3R4; and R4 or R3 is independently selected from the hydrogen, the alkyl and naphthenic base, or R4 and R3 are combined to form a substituted or non-substituted heterocyclic group, wherein the substituted group is the alkyl or hydroxyalkyl. |
| priorityDate | 2010-06-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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