| abstract |
The invention relates to a G-CSF (Granulocyte-Colony Stimulating Factor) fusion protein mutant, a preparation method and application thereof. The G-CSF fusion protein mutant is fusion protein having the effect of stimulating the proliferative activity of neutrophile granulocytes, and the structure of the G-CSF fusion protein mutant is G-CSF/carrier protein or carrier protein/G-CSF, wherein the G-CSF part contains multi-site mutations, which changes the activity and the receptor affinity. Compared with the traditional like products, the G-CSF fusion protein mutant has longer half-life period and higher biologic activity. Through injecting a proper dosage of the medicinal preparation, the neutrophilic granulocytopenia can be treated. |