http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-101824027-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1e74277852f1aae0a3ff13f59a65456d |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C09K11-06 |
| filingDate | 2010-04-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2013-09-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ab512540c4b99ffa4089b414f3e018cd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cc0f180992ec27f52633e140a84ac868 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d5867e58937855deae83edcd35b7fbc1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_630e1419ed35deaccd24b692b85a6b34 |
| publicationDate | 2013-09-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-101824027-B |
| titleOfInvention | Polysubstituted tetrahydroquinoline derivative with optical activity and synthetic method and use thereof |
| abstract | The invention discloses a polysubstituted tetrahydroquinoline derivative with optical activity and a synthetic method and a use thereof. The synthetic method comprises the following steps: taking palladium as a catalyst, and mixing an indole compound, an alkyne compound and an organic mixed solvent together for carrying out indole cyclization reaction, wherein the organic mixed solvent consists of acetonitrile, DMF or DMSO and aromatic acid, such as alkyl acid or benzoic acid. As an important molecular cut block, the polysubstituted tetrahydroquinoline derivative has a certain optical activity and is a great green emission substance. The synthetic method firstly uses the palladium as the catalyst and leads the indole compound and the alkyne compound to generate the polysubstituted tetrahydroquinoline derivative under the condition of taking air or oxygen as an oxidant. The method greatly keeps the atom economy and has a plurality of advantages of high yield, simple conditions, easy obtainment of raw materials, simple reaction equipment, easy realization of industrial production and the like. |
| priorityDate | 2010-04-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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