| abstract |
Tetrahydropyranucleoside analogs, oligomeric compounds prepared therefrom, and methods of using the oligomeric compounds are described. More specifically, tetrahydropyranucleoside analogs having one or more chiral substituents are provided that are useful for enhancing properties of oligomeric compounds, including nuclease resistance and binding affinity. In some embodiments, an oligomeric compound provided herein hybridizes to a portion of a target RNA such that the target RNA loses normal function. |