http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-101812054-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4c0ed78c4d5c4951a22374d61ea1f178 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 |
| filingDate | 2010-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-01-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dc66263cf443aa37084ef1b94df9e29c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5410ae2a96f5d5a860d96a94bfc534c5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cc8a0104bc9841677a8d9a610d23dcaf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_553ce16fcf2b675056f17842d483f4d6 |
| publicationDate | 2014-01-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-101812054-B |
| titleOfInvention | 1-acetyl-N-phenyl-N-(3-(4-(3-phenyl-1-H-pyrazole-5-radial)piperidine-1-radical)propyl)-4-amide derivative and preparation method thereof |
| abstract | The invention relates to a 1-acetyl-N-phenyl-N-(3-(4-(3-phenyl-1-H-pyrazole-5-radical)piperidine-1-radical)propyl)-4-amide and a derivative thereof, wherein R1 represents -H, -F, -C1, -Br, -CH3, -CH2CH3, -OCH3, -NO2 or -CN; R2 represents -H, -CH3, -Cl, -NO2 or -CN; and R3 represents -CH3 or -CF3. The invention also relates to a preparation method of the compound, which comprises the steps of: synthesizing N-chlorinated alkyl substituted aniline by using substituted aniline and 1-bromine-3-chloropropane as raw materials; enabling the compound to react with N-acetyl-piperidine acyl chloride for preparing an intermediate of 1-acyl-N-(3-propyl chloride)-N-phenyl piperidine-4-amide; and reacting with 4-(3-substituted phenyl-1-hydrogen pyrazole-5-radical) piperidine for generating corresponding 1-acetyl-N-phenyl-N-(3-(4-(3-phenyl-1-hydrogen-pyrazole-5-radical) piperidine-1-radical) propyl)-4-amide. The compound is applied for preparing HIV-1 inhibitors. |
| priorityDate | 2010-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 123.