http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-101735209-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2565e239961ad6938b046b5eaf86ce36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_77df63e490ab6fdc01396aaf632620b0 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B53-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D495-04 |
| filingDate | 2008-11-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2012-01-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2a3330631c9ce204602714a1b3319cd1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6a21cd449d2bfe927d57fa0b7134e5dc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1504e66dcf9fa3973811a2b69750cdd4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_878a01790e740b86cdb3194952b541d8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0d02d130f910548f792bb1c04280b905 |
| publicationDate | 2012-01-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-101735209-B |
| titleOfInvention | Method for synthesizing chiral dorzolamide hydrochloride |
| abstract | The invention discloses a compound represented by a general formula 1 and a preparation method thereof. In the structural formula, X=Y=O, or X=S, Y=O, or X=Y=S; and R represents phenyl, benzyl or isopropyl. The invention also discloses a method for synthesizing a compound represented by a general formula 3, and a method for synthesizing chiral dorzolamide hydrochloride, which are formed by carrying out one step reaction and multi-step reaction on the compound represented by the general formula 1. The compound synthesizes the chiral dorzolamide hydrochloride used for treating glaucoma by adopting a classical chiral prosthetic group induction method, and has the advantages of good yield, no racemization and high optical purity. |
| priorityDate | 2008-11-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 25.