http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-101723918-B
Outgoing Links
Predicate | Object |
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assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_95b060e7e455ae4f16e7ebf309652bd8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_dec340aa08c4b66773ca358855e6313a |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 |
filingDate | 2008-10-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate | 2011-08-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_edb351956d8b29b098eec7c9621c1881 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_03cb01d64c70a687842363b1a3a55ccc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3b0000fda6d1b7059e2ab2ed4dc516f9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_53a697f8627800a934418648ebbc0e19 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aee1b4031d678168937088653604d6ad http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7e7ee48a3e49bd1608185733a10ee5f2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a19722553c7223470dfad35f26c051f5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c61fae1a3d0bd6fa266f61d91ae88622 |
publicationDate | 2011-08-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | CN-101723918-B |
titleOfInvention | Process for preparing cinepazide maleate |
abstract | The invention relates to a new process for preparing cinepazide maleate, which comprises the following steps of: preparing chloracetyl pyrrolizidine; preparing 3,4,5-trimethoxy cinnamoyl chloride; preparing 3,4,5-trimethoxy piperazine cinnamate; preparing 1-[(1-pyrrolidine carbonyl)-methyl]-4-[3,4,5 a-trimethoxy cinnamyl] piperazine; preparing 1-[(1-pyrrolidine carbonyl)-methyl]-4-[3,4,5 a-trimethoxy cinnamyl] piperazine maleate; and purifying the cinepazide maleate and preparing a stable crystal form, wherein in the steps of preparing the cinepazide maleate, the 3,4,5-trimethoxy piperazine cinnamate is prepared first, and then the 3,4,5-trimethoxy piperazine cinnamate reacts with the chloracetyl pyrrolizidine in an alcohol to obtain cinepazide. A product prepared by the method for preparing the cinepazide maleate has the melting point of 171 to 173 DEG C. The product prepared by the method for preparing the cinepazide maleate has the advantages of high melting point, stable crystal form, obviously improved yield, greatly reduced production cost, and suitability for industrial large-scale production. |
priorityDate | 2008-10-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 30.